A randomised controlled trial to compare the efficacy of an aluminium lactate/potassium nitrate/hydroxylapatite toothpaste with a control toothpaste for the prevention of dentine hypersensitivity

To determine the efficacy of a cosmetic aluminium lactate/potassium nitrate/hydroxylapatite toothpaste for reduction dentine hypersensitivity (DH) pain as compared to control containing potassium nitrate. The study was randomised, examiner-blind, two treatment arm, parallel controlled trial in healthy adults with at least 2 sensitive teeth (Schiff >2). At baseline, immediately after and 7 14 days twice-daily brushing test or sensitivity measured following iced-water VAS) tactile (Yeaple probe) stimuli, whole mouth plaque score obtained. Participants also completed whole-mouth VAS DHEQ15 quality life questionnaire days. Both toothpastes reduced DH teeth, but group significantly better all timepoints by measures (p = 0.005, tooth-level brushing; p < 0.001 other comparisons). There relative risk Schiff 55 % which rose 81 88.6 (all 0.001). were no differences plaque, scores any time point. This demonstrated an nitrate prevention both over week period. agent appears have potential alleviation from common oral condition further research is warranted. pain, whilst transient nature, arresting magnitude, affecting life. Daily application efficacious can relieve however, yet, there gold standard treatment. results this support investigation management.